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Scientist/Senior Scientist-Remote (In Silico Protein Design)

Company: Invenra
Location: Fort Worth
Posted on: January 17, 2022

Job Description:

About Invenra:

We are a rapidly expanding and well-funded biotechnology company focused on employing cutting edge protein engineering and multi-specific antibodies to discover therapeutic solutions to challenging diseases. At Invenra, we start with biology, then employ our extensive technology toolbox and efficient discovery engine to design and create first- and best-in-class drug candidates. Using our proprietary B-BODY---, SNIPER--- and CLUSTR--- technologies, we have generated a robust pipeline of next-generation multi-specific antibodies to address unmet therapeutic needs in immuno-oncology and autoimmunity. Invenra's employee-focused management and flexible work environment creates a culture of energy and innovation where everyone makes a difference, and everyone benefits from success. For more information, please visit .

Position Summary:

Invenra is assembling a world-class team to work in our virology group, pursuing the discovery of biotherapeutics against major viral threats including Ebola, Lassa, and Marburg. Invenra is seeking a highly motivated scientist with extensive experience in In Silico Protein Design to join our new virology team, where they will be creating the fundamental subunits of our novel therapeutics. Reporting to the Head of Discovery and Protein Science, this individual will use RosettaDesign or other state-of-the-art protein design software to design de novo hyperstable binding modules, useful targets, and complete therapeutic molecules. The candidate will also design libraries for use in selections to identify hits and leads. In addition, the candidate may be coordinating academic or CRO collaborations in the areas of protein design and viral inhibition. The position requires direct experience with de novo protein design and excellent scientific and problem-solving skills, with a strong focus on creative solutions to technical problems.

Key Responsibilities:

  • Establish top quality protein design expertise at Invenra.
  • Design hyper-stable protein domains, libraries, and target structures.
  • Analyze target structures, create novel binding surfaces and scaffolds.
  • Coordinate collaborations and sponsored research activities with academic and CRO labs.
  • Contribute ideas that could lead to new antiviral drug designs.
  • Lead a discovery project in the antiviral group.
  • Assemble reports on progress and results, for inclusion in Invenra's quarterly reporting requirement to the contracting agency.

    Please note : This position does not require relocation. It may be remote OR on-site in Madison, WI.

    Required Education, Experience, and Competencies:
    • PhD OR a Master's degree with 3+ years of post-graduate experience in biophysics, biochemistry, or a related field. Prior industry experience is a plus.
    • Expertise in protein design software such as RosettaDesign.
    • Hands on experience designing de novo proteins or hyperstable versions of existing structures.
    • Experience with scripting languages such as Python.
    • Ability to work well independently and collaboratively in a team environment.
      • Demonstrated success with at least one of the following:
        • In silico design or modulation of a protein-protein interface
        • Evaluating and minimizing immunogenic risk
        • Incorporating pH dependence in binding interfaces
        • Designing libraries for in vitro selection
        • Experience in the field of biotherapeutic discovery
          Note: All candidates must be authorized to work in the United States.


          Includes a competitive compensation and benefits package composed of health and dental benefits, 401k match, stock option grants, PTO, tuition reimbursement, a generous bonus plan and relocation assistance. At Invenra, we believe in maintaining the highest ethical standards and ensuring that all employees have a good work-life balance.

          Invenra is an Equal Opportunity Employer. Invenra is committed to a diverse workforce. We believe every individual brings their own unique experience, and these experiences foster innovation and success. We are enthusiastically inclusive of age, race, creed, color, disability, marital status, sex, national origin, ancestry, sexual orientation, and military service.

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Keywords: Invenra, Fort Worth , Scientist/Senior Scientist-Remote (In Silico Protein Design), Other , Fort Worth, Texas

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